教授
张淑仪
程建春
陈伟中
王新龙
刘晓峻
章东
沈勇
刘晓宙
吴浩东
杨跃涛
屠娟
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屠娟
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屠娟
,教授
Juan Tu, Professor
2007 南京大学青年骨干教师
2011 教育部新世纪优秀人才支持计划
 
地址:江苏省南京市汉口路22号 南京大学声学研究所,210093
电话: 83594184
电子邮件 juantu@@nju.edu.cn

教育背景和工作经历
1994.9-1998.6 南京大学电子科学与工程系   本科
1998.9-2001.6 南京大学电子科学与工程系声学研究所    硕士
2001.6-2002.5 美国耶鲁大学(Yale University)机械工程系硕士
2002. 8-2006.6 美国华盛顿大学(University of Washington)生物工程系    博士
2006.7-2006.12 美国华盛顿大学应用物理实验室工业与医学超声中心   博士后
2007.1-2008.12 南京大学电子科学与工程系    讲师
2009.1-2013.12 南京大学物理学院声科学与工程系    副教授
2014.1-至今 南京大学物理学院声科学与工程系    教授

研究领域:
声空化、医学超声
 
承担的科研项目:
1、声/磁多功能造影剂微泡的包膜特性、动力学响应及生物效应研究(国家自然科学基金,2015.1-2018.12)
2、微气泡稳态声空化微流场对细胞膜通透性和细胞估计的作用机制研究(国家自然科学基金,2013.1-2016.12)
3、利用微泡声空化效应增强含VEGF生长因子皮肤组织工程材料疗效的研究(国家自然科学基金,2011.1-2013.12)
4、超声驱动下管中微气泡的动力学行为 (国家自然科学基金青年基金,2008.1-2010.12)



教学情况:
1、概率论与随机过程(本科生)

学术兼职:
1、美国声学学会会士
2、中国超声医学工程学会超声生物效应专业委员会委员
 
发表论文目录(“*”表示为通讯作者)

  1. Chunbing Zhang, Fengmeng Teng, Juan Tu*, Dong Zhang, Ultrasound-enhanced protective effect of tetramethylpyrazine against cerebral ischemia/reperfusion injury Ultrasound-enhanced protective effect of tetramethylpyrazine against cerebral ischemia/reperfusion injury, PLos One, 2014: 9(11): e113673

  2. Gepu Guo, Lu Lu, Leilei Yin, Juan Tu*, Xiasheng Guo, Junru Wu, Di Xu, Dong Zhang, Mechanical and dynamic characteristics of encapsulated microbubbles coupled by magnetic nanoparticles as multifunctional imaging and drug delivery agents, Phys. Med. Biol., 2014, 59(22): 6729-6747.

  3. Zhou Lin, Xiasheng Guo, Juan Tu, Jianchun Cheng, Junru Wu, Dong Zhang, Acoustic focusing of sub-wavelength scale achieved by multiple Fabry-Perot resonance effect, J. Appl. Phys., 2014, 115: 104504. 

4.Tao ChenTingbo FanWei ZhangYuanyuan Qiu, Juan Tu*, Xiasheng GuoDong ZhangAcoustic characterization of high intensity focused ultrasound fields generated from a transmitter with a large aperture, J. Appl. Phys., 2014, 115(11): 14902
5.Zhenbo LiuXiasheng Guo, Juan Tu*, Dong ZhangVariations in Temperature Distribution and Tissue Lesion Formation Induced by Tissue Inhomogeneity for Therapeutic Ultrasound, Ultra. Med. Biol., 2014, 40(8): 1857-1868.
6.Jie Yu, Chuyi Chen, Gong Chen, Xiasheng Guo, Yong Ma, Juan Tu*, Dong Zhang, Real-Time Monitoring and Quantitative Evaluation of Cavitation Bubbles Induced by High Intensity Focused Ultrasound Using B-Mode Imaging, Chin. Phys. Lett., 2014, 31(3): 034302.
7.Hao Geng, Tinbo Fan, Zhe Zhang, Juan Tu, Xiasheng Guo, Faqi Li, Dong Zhang, Tissue lesion induce by a spherical cavity transducer, Acta Phys. Sinica, 2014, 63(4): 044301
8.Lu Gao, Haixiang Zheng, Qingyu Ma, Juan Tu, Dong Zhang, Linear phase distribution of acoustical vortices, J. Appl. Phys., 2014, 116(2): 024905
  1. F. Cavalieri, J.P. Best, C. Perez, CJ. Tu, F. Caruso, T. J. Matula, M. Ashokkumar, Mechanical Characterization of Ultrasonically Synthesized Microbubble Shells by Flow Cytometry and AFM, ACS Appl. Mater. Interfaces, 2013, 5(21): 10920-10925

  2. Xiasheng Guo, Qian Li, Zhe Zhang, Dong Zhang, Juan Tu*, Investigation on the inertial cavitation threshold and shell properties of commercialized ultrasound contrast agent microbubbles, J. Acoust. Soc. Am., 2013, 134(2): 1622-1631

  3. Xiaofeng Wang, Thomas J. Matula, Yong Ma, Zheng Liu, Juan Tu*, et al., Finite element modeling of acoustic wave propagation and energy deposition in bone during extracorporeal shock wave treatment, J. Appl. Phys., 2013, 113(24): 244901

  4. Qian Li, T.J. Matula, Juan Tu*, et al, Modeling complicated rheological behaviors in encapsulating shells of lipid-coated microbubbles accounting for nonlinear changes of both shell viscosity and elasticity, Phys. Med. Biol., 2013, 58(4):985-998;

  5. Xiasheng Guo, Zhou Lin, Juan Tu, et. al, Modeling and optimization of an acoustic diode based on micro-bubble nonlinearity, J. Acoust. Soc. Am., 2013, 133(2): 1119-1125;

  6. Chunbing Zhang, Huilin Cao, Qian Li, Juan Tu*, et. al., Enhancement effect of ultrasound-induced microbubble cavitation on branched polyethylenimine-mediated VEGF165 transfection with varied N/P ratio, Ultrasound Med. Biol., 2013, 39(1): 161-171;

  7. Faqi Li, Hua Wang, Deping Zeng, Tinbo Fan, Hao Geng, Juan Tu, Xiasheng, Guo, Xiufeng Gong, Chunliang Zhao, Zhilong Wang, Dong Zhang, Zhibiao Wang, Sub-wavelength ultrasonic therapy using a spherical cavity transducer with open ends,Appl. Phys. Lett. 102: 204102, 2013

  8. Ling Yang, Qinyu Ma, Juan Tu, Dong Zhang, Phase-coded approach for controllable generation of acoustical vortices, J. Appl. Phys., 2013, 113(15): 154904

  9. Juan Tu, Joo-Ha Hwang, et. al., Controllable in vivo hyperthermia effect induced by pulsed high intensity focused ultrasound with low duty cycles, Appl. Phys. Lett., 2012, 101(12): 124102;

  10. Weicheng Cui, Juan Tu*, JH Hwang, Qian Li, Tinbo Fan, Dong Zhang, Jinghai Chen, Weizhong Chen, In vivo hyperthermia effect induced by high intensity pulsed ultrasound; Chin. Phys. B.; 2012, 7: 074301;

  11. Yong Li, Juan Tu, Bin Liang, et. al., Unidirectional acoustic transmission based on source pattern reconstruction, J. Appl. Phys., 2012, 112(6):064504

  12. Weicheng Cui, Weizhong Chen, Shuibao Qi, Chao Zhou, Juan Tu, Radial and translational oscillations of an acoustically levitated bubble in aqueous ethanol solutions, J. Acoust. Soc. Am., 2012, 132(1): 138-143;

  13. Yuanyuan Qiu, Chunbing Zhang, Juan Tu, Dong Zhang, Microbubble-induced sonoporation involved in ultrasound-mediated DNA transfection in vitro at low acoustic pressures; J. Biomechanics; 2012, 45(8): 1339-1345;.

  14. Weicheng Cui, Shuibao Qi, Weizhong Chen, Chao Zhou, Juan Tu, Effect of alcohol on single-bubble sonoluminescence; Phys. Rev. E; 2012, 85(2): 026304;

  15. Xiaodong Sun, Feng Zhang, Qinyu Ma, D Zhang, Juan Tu, Acoustic dipole radiation based conductivity image reconstruction for magnetoacoustic tomography with magnetic induction; Appl. Phys. Lett.; 2012, 100(2): 024105;

  16. Xiaofeng Wang, Dong Zhang, Juan Tu*, Inertial cavitation threshold measurements for Optison and Sonovue, J. Nanjing Univ., 2012, 48(5): 559-564

  17. Juan Tu, JE Swalwell, D Giraud, et. al, Microbubble sizing and shell characterization using flow cytometry, IEEE Trans. UFFC, 2011, 58(5): 966-963.

  18. Yuanyuan Qiu, Yi Luo, Yanli Zhang, Weicheng Cui, Dong Zhang, Junru Wu, Junfeng Zhang, Juan Tu*, The correlation between acoustic cavitation and sonoporation involved in ultrasound-mediated DNA transfection with polyethylenimine (PEI) in vitro. J. Control Release, 2010, 145(1), 40-48.

  19. Bin Liang, Xiasheng Guo, Juan Tu, Dong Zhang, Jianchun Cheng, An acoustic rectifier, Nature Materials, 2010, 9(12), 989-992.

  20. WW Kan, B Liang, XF Zhu, Juan Tu, et. al., Nonpropagating X-shaped acoustic waves in sonic crystals without defects, Appl. Phys. Lett., 2010, 97: 223504.

  21. Juan Tu, Jingfeng Guan, Yuanyuan Qiu, et.al., Estimating the shell parameters of Sonovue microbubbles using light scattering. J. Acoust. Soc. Am., 2009, 126(6):2954-2962.

  22. Lujie Zheng, Juan Tu, Weizhong Chen, Modeling of ultrasound contrast agents bubble dynamics with modified surface tension coefficient, Chin. Sci. Bull., 2009, 54(10):3501-3507.

  23. Juan Tu, J. F. Guan, T.J. Matula, L. A. Crum and R. J. Wei. Real-time measurements and modeling on the dynamic behaviors of SonoVue bubbles based on light scattering technology. Chin. Phys. Lett. 2008, 25:172.

  24. Juan Tu, T. J. Matula, M. R. Bailey and L.A. Crum. Evaluation of a shock wave induced cavitation activity both in vitro and in vivo. Phys. Med. Biol. 2007, 52:5933.

  25. Juan Tu, Joo Ha Hwang, T. J. Matula, A. Brayman, and L. Crum. Intravascular inertial cavitation activity detection and quantification in vivo with optison. Ultrasound Med. Biol. 2006; 32(10):1601.

  26. Joo Ha Hwang, Juan Tu, A.A.Brayman, T.J. Matula, and L. A. Crum. Correlation between inertial cavitation dose and endothelial cell damage in vivo. Ultrasound Med. Biol.2006, 32(10):1611.

  27. Juan Tu, T. Matula and L. Crum. Inertial Cavitation Dose Produced in Ex Vivo Rabbit Ear Arteries by 1-MHz insonation treatment during infusion with Optison, Ultrasound Med. Biol., 2006; 32(2):281.

  28. Juan Tu, Han Lin, Lei Lu, Weizhong Chen, Rongjue Wei,  Spatiotemporal evolution form a pair of like polarity solitons to chaos, Phys. Lett. A, 2002; 304:79.

37.         Weizhong Chen, Juan Tu, Rongjue Wei, Onset instability to nonpropagating hydrodynamic solitons, Phys. Lett. A, 1999; 255:272
 
授权发明专利:

  1. 程建春,梁彬,章东,郭霞生,屠娟;2012, 一种声二极管及检测声二极管的系统,专利授权号: CN102175300

  2. 程建春,梁彬,章东,郭霞生,屠娟,2013 Acoustic Diode, 专利授权号:US8511423B2

 
教科书和专著章节:
1、 章东,郭霞生,马青玉,屠娟, 医学超声基础, 科学出版社, 2014年5月,Ch10-12